6EYO

Structure of extended IgE-Fc in complex with two anti-IgE Fabs

Summary for 6EYO

• Entry DOI: 10.2210/pdb6eyo/pdb
• Descriptor: Immunoglobulin heavy constant epsilon, 8D6 Fab heavy chain, 8D6 Fab light chain, ... (5 entities in total)
• Functional Keywords: immunoglobulin e, fab, antibody, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 171734.64

Authors

Chen, J.B.,Ramadani, F.,Pang, M.O.Y.,Beavil, R.L.,Holdom, M.D.,Mitropoulou, A.N.,Beavil, A.J.,Gould, H.J.,Chang, T.W.,Sutton, B.J.,McDonnell, J.M.,Davies, A.M. (deposition date: 2017-11-13, release date: 2018-08-15, Last modification date: 2024-01-17)

• Primary citation: Chen, J.B.,Ramadani, F.,Pang, M.O.Y.,Beavil, R.L.,Holdom, M.D.,Mitropoulou, A.N.,Beavil, A.J.,Gould, H.J.,Chang, T.W.,Sutton, B.J.,McDonnell, J.M.,Davies, A.M.; Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.; Sci Rep, 8:11548-11548, 2018; PubMed: 30069035; DOI: 10.1038/s41598-018-29664-4

Experimental method

X-RAY DIFFRACTION (3.7 Å)