6EYO
Structure of extended IgE-Fc in complex with two anti-IgE Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin heavy constant epsilon | polymer | 327 | 36354.8 | 2 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (Human) | Ig epsilon chain C region,Ig epsilon chain C region ND |
| 2 | C, D (I, H) | 8D6 Fab heavy chain | polymer | 227 | 24555.3 | 2 | Homo sapiens | ||
| 3 | E, F (M, L) | 8D6 Fab light chain | polymer | 218 | 23803.2 | 2 | Homo sapiens | ||
| 4 | G (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 5 | H (D) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) |
Sequence modifications
A, B: 224 - 547 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Asp 222 | - | expression tag |
| Ile 223 | - | expression tag |
| Ala 225 | Cys 105 | conflict |
| Gln 265 | Asn 146 | conflict |
| Gln 371 | Asn 252 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169426.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2308.1 | |
| All* | Total formula weight | 171734.6 |
