6EW8
Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand
Summary for 6EW8
Entry DOI | 10.2210/pdb6ew8/pdb |
Related | 5N1X 5N1Z 5N20 5N21 |
Descriptor | B-cell lymphoma 6 protein, CHLORIDE ION, anilinopyrimidine ligand, ... (4 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14824.98 |
Authors | Robb, G.,Ferguson, A.,Hargreaves, D. (deposition date: 2017-11-03, release date: 2018-10-24, Last modification date: 2024-05-08) |
Primary citation | McCoull, W.,Cheung, T.,Anderson, E.,Barton, P.,Burgess, J.,Byth, K.,Cao, Q.,Castaldi, M.P.,Chen, H.,Chiarparin, E.,Carbajo, R.J.,Code, E.,Cowan, S.,Davey, P.R.,Ferguson, A.D.,Fillery, S.,Fuller, N.O.,Gao, N.,Hargreaves, D.,Howard, M.R.,Hu, J.,Kawatkar, A.,Kemmitt, P.D.,Leo, E.,Molina, D.M.,O'Connell, N.,Petteruti, P.,Rasmusson, T.,Raubo, P.,Rawlins, P.B.,Ricchiuto, P.,Robb, G.R.,Schenone, M.,Waring, M.J.,Zinda, M.,Fawell, S.,Wilson, D.M. Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6. ACS Chem. Biol., 13:3131-3141, 2018 Cited by PubMed: 30335946DOI: 10.1021/acschembio.8b00698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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