6EO0
Zebrafish Sirt5 in complex with stalled peptidylimidate and bicyclic intermediate of inhibitory compound 29
Summary for 6EO0
Entry DOI | 10.2210/pdb6eo0/pdb |
Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | hydrolase, ptm, inhibitor, signaling protein |
Biological source | Danio rerio (Zebrafish) |
Cellular location | Mitochondrion : Q6DHI5 |
Total number of polymer chains | 4 |
Total formula weight | 129146.92 |
Authors | Pannek, M.,Steegborn, C. (deposition date: 2017-10-08, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Rajabi, N.,Auth, M.,Troelsen, K.R.,Pannek, M.,Bhatt, D.P.,Fontenas, M.,Hirschey, M.D.,Steegborn, C.,Madsen, A.S.,Olsen, C.A. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew. Chem. Int. Ed. Engl., 56:14836-14841, 2017 Cited by PubMed: 29044784DOI: 10.1002/anie.201709050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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