6EGA

IRAK4 in complex with a type II inhibitor

Summary for 6EGA

• Entry DOI: 10.2210/pdb6ega/pdb
• Descriptor: Interleukin-1 receptor-associated kinase 4, 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71349.88

Authors

Wang, L.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-20, Last modification date: 2024-03-13)

• Primary citation: Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.; Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).; J.Biol.Chem., 294:4511-4519, 2019; PubMed: 30679311; DOI: 10.1074/jbc.RA118.005428

Experimental method

X-RAY DIFFRACTION (2.512 Å)