6E5B
Human Immunoproteasome 20S particle in complex with compound 1
Summary for 6E5B
Entry DOI | 10.2210/pdb6e5b/pdb |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-8, ... (18 entities in total) |
Functional Keywords | multicatalytic proteinase, 20s proteasome, protease, proteros, proteros biostructures gmbh, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 28 |
Total formula weight | 761477.64 |
Authors | Steinbacher, S.,Augustin, M.,Blaesse, M.,Harris, S.F. (deposition date: 2018-07-19, release date: 2019-09-11) |
Primary citation | Ladi, E.,Everett, C.,Stivala, C.E.,Daniels, B.E.,Durk, M.R.,Harris, S.F.,Huestis, M.P.,Purkey, H.E.,Staben, S.T.,Augustin, M.,Blaesse, M.,Steinbacher, S.,Eidenschenk, C.,Pappu, R.,Siu, M. Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability. J.Med.Chem., 62:7032-7041, 2019 Cited by PubMed: 31283222DOI: 10.1021/acs.jmedchem.9b00509 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
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