6E5B

Human Immunoproteasome 20S particle in complex with compound 1

Summary for 6E5B

Entry DOI	10.2210/pdb6e5b/pdb
Descriptor	Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-8, ... (18 entities in total)
Functional Keywords	multicatalytic proteinase, 20s proteasome, protease, proteros, proteros biostructures gmbh, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	28
Total formula weight	761477.64
Authors	Steinbacher, S.,Augustin, M.,Blaesse, M.,Harris, S.F. (deposition date: 2018-07-19, release date: 2019-09-11)
Primary citation	Ladi, E.,Everett, C.,Stivala, C.E.,Daniels, B.E.,Durk, M.R.,Harris, S.F.,Huestis, M.P.,Purkey, H.E.,Staben, S.T.,Augustin, M.,Blaesse, M.,Steinbacher, S.,Eidenschenk, C.,Pappu, R.,Siu, M. Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability. J.Med.Chem., 62:7032-7041, 2019 Cited by PubMed: 31283222 DOI: 10.1021/acs.jmedchem.9b00509 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation