6E5B

Human Immunoproteasome 20S particle in complex with compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000502	cellular_component	proteasome complex
a	0001530	molecular_function	lipopolysaccharide binding
a	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0036064	cellular_component	ciliary basal body
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
a	0070062	cellular_component	extracellular exosome
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0009615	biological_process	response to virus
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0034774	cellular_component	secretory granule lumen
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
b	0000502	cellular_component	proteasome complex
b	0002376	biological_process	immune system process
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006508	biological_process	proteolysis
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
b	0070062	cellular_component	extracellular exosome
b	1990111	cellular_component	spermatoproteasome complex
b	2000116	biological_process	regulation of cysteine-type endopeptidase activity
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0098794	cellular_component	postsynapse
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034774	cellular_component	secretory granule lumen
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000502	cellular_component	proteasome complex
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045202	cellular_component	synapse
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0052548	biological_process	regulation of endopeptidase activity
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
H	0000502	cellular_component	proteasome complex
H	0000902	biological_process	cell morphogenesis
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006508	biological_process	proteolysis
H	0006959	biological_process	humoral immune response
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0042098	biological_process	T cell proliferation
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
H	1990111	cellular_component	spermatoproteasome complex
I	0000502	cellular_component	proteasome complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0010243	biological_process	response to organonitrogen compound
J	0010498	biological_process	proteasomal protein catabolic process
J	0014070	biological_process	response to organic cyclic compound
J	0016020	cellular_component	membrane
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
K	0000502	cellular_component	proteasome complex
K	0002376	biological_process	immune system process
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006508	biological_process	proteolysis
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0019882	biological_process	antigen processing and presentation
K	0030154	biological_process	cell differentiation
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045444	biological_process	fat cell differentiation
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0052548	biological_process	regulation of endopeptidase activity
K	0070062	cellular_component	extracellular exosome
K	1990111	cellular_component	spermatoproteasome complex
L	0000502	cellular_component	proteasome complex
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0034774	cellular_component	secretory granule lumen
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
L	0070062	cellular_component	extracellular exosome
L	1904813	cellular_component	ficolin-1-rich granule lumen
M	0000502	cellular_component	proteasome complex
M	0001530	molecular_function	lipopolysaccharide binding
M	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0036064	cellular_component	ciliary basal body
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
M	0070062	cellular_component	extracellular exosome
N	0000502	cellular_component	proteasome complex
N	0002376	biological_process	immune system process
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006508	biological_process	proteolysis
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
N	0070062	cellular_component	extracellular exosome
N	1990111	cellular_component	spermatoproteasome complex
N	2000116	biological_process	regulation of cysteine-type endopeptidase activity
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0009615	biological_process	response to virus
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0098794	cellular_component	postsynapse
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0045202	cellular_component	synapse
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0052548	biological_process	regulation of endopeptidase activity
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0003723	molecular_function	RNA binding
U	0004175	molecular_function	endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0035639	molecular_function	purine ribonucleoside triphosphate binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0070062	cellular_component	extracellular exosome
V	0000502	cellular_component	proteasome complex
V	0000902	biological_process	cell morphogenesis
V	0004175	molecular_function	endopeptidase activity
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0006508	biological_process	proteolysis
V	0006959	biological_process	humoral immune response
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0042098	biological_process	T cell proliferation
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
V	1990111	cellular_component	spermatoproteasome complex
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0070062	cellular_component	extracellular exosome
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0010243	biological_process	response to organonitrogen compound
X	0010498	biological_process	proteasomal protein catabolic process
X	0014070	biological_process	response to organic cyclic compound
X	0016020	cellular_component	membrane
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0000502	cellular_component	proteasome complex
Y	0002376	biological_process	immune system process
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006508	biological_process	proteolysis
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0019882	biological_process	antigen processing and presentation
Y	0030154	biological_process	cell differentiation
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0045444	biological_process	fat cell differentiation
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0052548	biological_process	regulation of endopeptidase activity
Y	0070062	cellular_component	extracellular exosome
Y	1990111	cellular_component	spermatoproteasome complex
Z	0000502	cellular_component	proteasome complex
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0019774	cellular_component	proteasome core complex, beta-subunit complex
Z	0034774	cellular_component	secretory granule lumen
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SCN E 301

Chain	Residue
E	ARG126
E	TYR128

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA G 301

Chain	Residue
G	THR14
G	TYR125
G	ASN128
G	MET131

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NA H 301

Chain	Residue
Z	ASP213
H	ILE163
H	ASP166
H	SER169

---

site_id	AC4
Number of Residues	3
Details	binding site for residue NA I 301

Chain	Residue
I	VAL175
I	ASP178
I	SER181

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA I 302

Chain	Residue
I	ASP205
Y	ARG19
Y	THR164
Y	ASP167
Y	SER168
Y	SER170

---

site_id	AC6
Number of Residues	8
Details	binding site for residue HUJ K 901

Chain	Residue
K	THR1
K	ALA20
K	SER21
K	GLY47
K	CYS48
K	ALA49
K	TYR169
L	HOH401

---

site_id	AC7
Number of Residues	7
Details	binding site for residue NA K 902

Chain	Residue
K	ARG19
K	THR164
K	ASP167
K	SER168
K	SER170
K	HOH1003
W	ASP205

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SCN L 301

Chain	Residue
K	SER27
L	SER123
L	SER129
L	LYS136

---

site_id	AC9
Number of Residues	3
Details	binding site for residue NA L 302

Chain	Residue
L	ALA183
L	ASP186
L	THR189

---

site_id	AD1
Number of Residues	4
Details	binding site for residue NA L 303

Chain	Residue
L	ASP213
V	ILE163
V	ASP166
V	SER169

---

site_id	AD2
Number of Residues	7
Details	binding site for residue HUJ N 901

Chain	Residue
N	THR1
N	VAL20
N	SER21
N	PHE31
N	LEU45
N	GLY47
N	ALA49

---

site_id	AD3
Number of Residues	3
Details	binding site for residue NA N 902

Chain	Residue
N	MET163
N	ASP166
N	SER169

---

site_id	AD4
Number of Residues	4
Details	binding site for residue NA U 301

Chain	Residue
U	THR14
U	TYR125
U	ASN128
U	MET131

---

site_id	AD5
Number of Residues	3
Details	binding site for residue NA W 301

Chain	Residue
W	VAL175
W	ASP178
W	SER181

---

site_id	AD6
Number of Residues	1
Details	binding site for residue SCN Z 301

Chain	Residue
Z	SER129

---

site_id	AD7
Number of Residues	3
Details	binding site for residue NA Z 302

Chain	Residue
Z	ALA183
Z	ASP186
Z	THR189

---

site_id	AD8
Number of Residues	4
Details	binding site for residue NA b 902

Chain	Residue
b	MET163
b	ASP166
b	SER169
b	HOH1001

---

site_id	AD9
Number of Residues	15
Details	binding site for Di-peptide HUJ Y 901 and THR Y 1

Chain	Residue
Y	THR2
Y	ASP17
Y	ALA20
Y	SER21
Y	GLY23
Y	LYS33
Y	MET45
Y	SER46
Y	GLY47
Y	ALA49
Y	GLY129
Y	SER130
Y	GLY131
Y	TYR169
Y	SER170

---

site_id	AE1
Number of Residues	13
Details	binding site for Di-peptide HUJ b 901 and THR b 1

Chain	Residue
b	THR2
b	ASP17
b	VAL20
b	SER21
b	GLY23
b	LYS33
b	GLY47
b	ALA49
b	GLY128
b	SER129
b	GLY130
b	SER168
b	SER169

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsaStFSPdGRvfQVEYAmkA

Chain	Residue	Details
F	TYR7-ALA29
C	TYR3-ALA25
E	TYR6-ALA28
A	TYR5-ALA27
G	PHE9-ALA31
B	TYR5-ALA27
D	TYR8-ALA30

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAMkGknCVAIAADrrfgiqaqmvttdfq.KifpmgdrlyiglaGlaTD

Chain	Residue	Details
I	MET12-ASP59
L	LEU13-ASP60
H	ALA4-ASP51
J	ILE5-ASP52
K	LEU4-ASP51
a	LEU12-ASP59
B	LEU35-ASP82
b	MET4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
N	THR1
b	THR1
G	SER64
U	SER17
U	SER63
U	SER64

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:O35955

Chain	Residue	Details
N	GLY0
b	GLY0
L	SER134
Z	SER34
Z	SER40
Z	SER134

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
N	LYS33
N	LYS89
b	LYS33
b	LYS89
O	SER13
O	SER15

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS176
Z	LYS176

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
L	SER30
L	SER181
Z	SER30
Z	SER181
S	LYS208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER198
R	SER198

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
A	TYR120
O	TYR120

---