6DVR

Crystal structure of human CARM1 with (R)-SKI-72

Summary for 6DVR

• Entry DOI: 10.2210/pdb6dvr/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... (5 entities in total)
• Functional Keywords: carm1, prmt4, ski-72 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 79783.07

Authors

Dong, A.,Zeng, H.,Hutchinson, A.,Seitova, A.,Luo, M.,Cai, X.C.,Ke, W.,Wang, J.,Shi, C.,Zheng, W.,Lee, J.P.,Ibanez, G.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2018-06-25, release date: 2018-07-25, Last modification date: 2023-10-11)

• Primary citation: Zeng, H.,Dong, A.,Hutchinson, A.,Seitova, A.,Luo, M.,Cai, X.C.,Ke, W.,Wang, J.,Shi, C.,Zheng, W.,Lee, J.P.,Ibanez, G.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC); Crystal structure of human CARM1 with (R)-SKI-72; to be published,

Experimental method

X-RAY DIFFRACTION (1.54 Å)