6DO1
Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8
Summary for 6DO1
Entry DOI | 10.2210/pdb6do1/pdb |
Descriptor | Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein, Nanobody Nb.AT110i1, Angiotensin-like peptide S1I8, ... (7 entities in total) |
Functional Keywords | nanobody, gpcr, synthetic antibody, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 156220.47 |
Authors | Wingler, L.M.,McMahon, C.,Staus, D.P.,Lefkowitz, R.J.,Kruse, A.C. (deposition date: 2018-06-08, release date: 2019-01-30, Last modification date: 2023-10-11) |
Primary citation | Wingler, L.M.,McMahon, C.,Staus, D.P.,Lefkowitz, R.J.,Kruse, A.C. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell, 176:479-490.e12, 2019 Cited by PubMed: 30639100DOI: 10.1016/j.cell.2018.12.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.901 Å) |
Structure validation
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