6CVH
Identification and biological evaluation of thiazole-based inverse agonists of RORgt
Summary for 6CVH
Entry DOI | 10.2210/pdb6cvh/pdb |
Descriptor | Nuclear receptor ROR-gamma, trans-3-({4-(cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-{[(2R)-1,1,1-trifluoropropan-2-yl]carbamoyl}phenyl]-1,3-thiazole-2-carbonyl}amino)cyclobutane-1-carboxylic acid (2 entities in total) |
Functional Keywords | nuclear receptor rorgt, nuclear protein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 1 |
Total formula weight | 27027.29 |
Authors | Spurlino, J.,Milligan, C. (deposition date: 2018-03-28, release date: 2018-04-25, Last modification date: 2024-03-13) |
Primary citation | Gege, C.,Cummings, M.D.,Albers, M.,Kinzel, O.,Kleymann, G.,Schluter, T.,Steeneck, C.,Nelen, M.I.,Milligan, C.,Spurlino, J.,Xue, X.,Leonard, K.,Edwards, J.P.,Fourie, A.,Goldberg, S.D.,Hoffmann, T. Identification and biological evaluation of thiazole-based inverse agonists of ROR gamma t. Bioorg. Med. Chem. Lett., 28:1446-1455, 2018 Cited by PubMed: 29631962DOI: 10.1016/j.bmcl.2018.03.093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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