6CVH
Identification and biological evaluation of thiazole-based inverse agonists of RORgt
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 227 | 26435.6 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B (A) | trans-3-({4-(cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-{[(2R)-1,1,1-trifluoropropan-2-yl]carbamoyl}phenyl]-1,3-thiazole-2-carbonyl}amino)cyclobutane-1-carboxylic acid | non-polymer | 591.7 | 1 | Chemie (FJG) |
Sequence modifications
A: 265 - 489 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Pro 490 | - | expression tag |
| Ala 491 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26435.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 591.7 | |
| All* | Total formula weight | 27027.3 |
