6CRF
Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation
Summary for 6CRF
Entry DOI | 10.2210/pdb6crf/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, GLYCEROL (3 entities in total) |
Functional Keywords | shp2, ptpn11, protein tyrosine phosphatase, e76k, gain of function mutant, open conformation, phosphatase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 120702.24 |
Authors | |
Primary citation | LaRochelle, J.R.,Fodor, M.,Vemulapalli, V.,Mohseni, M.,Wang, P.,Stams, T.,LaMarche, M.J.,Chopra, R.,Acker, M.G.,Blacklow, S.C. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9:4508-4508, 2018 Cited by PubMed: 30375388DOI: 10.1038/s41467-018-06823-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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