6CPG
Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation
Summary for 6CPG
Entry DOI | 10.2210/pdb6cpg/pdb |
Descriptor | Aurora kinase A, Monobody, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea (3 entities in total) |
Functional Keywords | protein kinase, dfg-loop, monobody, at9283, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 86452.35 |
Authors | Otten, R.,Kutter, S.,Zorba, A.,Padua, R.A.P.,Koide, A.,Koide, S.,Kern, D. (deposition date: 2018-03-13, release date: 2018-06-27, Last modification date: 2023-10-04) |
Primary citation | Pitsawong, W.,Buosi, V.,Otten, R.,Agafonov, R.V.,Zorba, A.,Kern, N.,Kutter, S.,Kern, G.,Padua, R.A.,Meniche, X.,Kern, D. Dynamics of human protein kinase Aurora A linked to drug selectivity. Elife, 7:-, 2018 Cited by PubMed: 29901437DOI: 10.7554/eLife.36656 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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