6CJG

Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46

Summary for 6CJG

Entry DOI	10.2210/pdb6cjg/pdb
Related	6CJF
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
Functional Keywords	oxidoreductase, oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42200.90
Authors	Petrunak, E.M.,Stuckey, J.A. (deposition date: 2018-02-26, release date: 2018-05-23, Last modification date: 2023-10-04)
Primary citation	Madak, J.T.,Cuthbertson, C.R.,Miyata, Y.,Tamura, S.,Petrunak, E.M.,Stuckey, J.A.,Han, Y.,He, M.,Sun, D.,Showalter, H.D.,Neamati, N. Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. J. Med. Chem., 61:5162-5186, 2018 Cited by PubMed: 29727569 DOI: 10.1021/acs.jmedchem.7b01862 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.851 Å)

Structure validation