6CJF
Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43
Summary for 6CJF
| Entry DOI | 10.2210/pdb6cjf/pdb |
| Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total) |
| Functional Keywords | oxidoreductase, oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 84465.90 |
| Authors | Petrunak, E.M.,Stuckey, J.A. (deposition date: 2018-02-26, release date: 2018-05-23, Last modification date: 2023-10-04) |
| Primary citation | Madak, J.T.,Cuthbertson, C.R.,Miyata, Y.,Tamura, S.,Petrunak, E.M.,Stuckey, J.A.,Han, Y.,He, M.,Sun, D.,Showalter, H.D.,Neamati, N. Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. J. Med. Chem., 61:5162-5186, 2018 Cited by PubMed: 29727569DOI: 10.1021/acs.jmedchem.7b01862 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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