6CJF
Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 374 | 40752.4 | 2 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | C, G (A, B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
| 3 | D, H (A, B) | OROTIC ACID | non-polymer | 156.1 | 2 | Chemie (ORO) | |||
| 4 | E, I (A, B) | 2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid | non-polymer | 406.8 | 2 | Chemie (F54) | |||
| 5 | F, J, K (A, B) | 3-[decyl(dimethyl)ammonio]propane-1-sulfonate | non-polymer | 307.5 | 3 | Chemie (ZWI) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 396 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| Leu 397 | - | expression tag |
| Glu 398 | - | expression tag |
| Ala 399 | - | expression tag |
| Gly 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81504.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2961.0 | |
| All* | Total formula weight | 84465.9 |
