6CJF

Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Dihydroorotate dehydrogenase (quinone), mitochondrial	polymer	374	40752.4	2	UniProt (Q02127) Pfam (PF01180) In PDB	Homo sapiens (Human)	DHOdehase,Dihydroorotate oxidase
2	A, B	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	2	Chemie (FMN)
3	A, B	OROTIC ACID	non-polymer		156.1	2	Chemie (ORO)
4	A, B	2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid	non-polymer		406.8	2	Chemie (F54)
5	A, B	3-[decyl(dimethyl)ammonio]propane-1-sulfonate	non-polymer		307.5	3	Chemie (ZWI)
6		water	water		18.0	365	Chemie (HOH)

Sequence modifications

A, B: 33 - 396 (UniProt: Q02127)

PDB	External Database	Details
Leu 397	-	expression tag
Glu 398	-	expression tag
Ala 399	-	expression tag
Gly 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	81504.9
Non-Polymers*	Number of molecules	9
	Total formula weight	2961.0
All*	Total formula weight	84465.9

*Water molecules are not included.