6CJF
Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004151 | molecular_function | dihydroorotase activity |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0005829 | cellular_component | cytosol |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006225 | biological_process | UDP biosynthetic process |
A | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
B | 0004151 | molecular_function | dihydroorotase activity |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0005829 | cellular_component | cytosol |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006225 | biological_process | UDP biosynthetic process |
B | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | binding site for residue FMN A 501 |
Chain | Residue |
A | ALA95 |
A | THR283 |
A | ASN284 |
A | THR285 |
A | SER305 |
A | GLY306 |
A | LEU309 |
A | VAL333 |
A | GLY334 |
A | GLY335 |
A | LEU355 |
A | ALA96 |
A | TYR356 |
A | THR357 |
A | ORO502 |
A | HOH615 |
A | HOH620 |
A | HOH675 |
A | GLY97 |
A | LYS100 |
A | SER120 |
A | ASN145 |
A | ASN181 |
A | ASN212 |
A | LYS255 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue ORO A 502 |
Chain | Residue |
A | LYS100 |
A | ASN145 |
A | TYR147 |
A | GLY148 |
A | PHE149 |
A | ASN212 |
A | ASN284 |
A | THR285 |
A | FMN501 |
site_id | AC3 |
Number of Residues | 18 |
Details | binding site for residue F54 A 503 |
Chain | Residue |
A | TYR38 |
A | MET43 |
A | LEU46 |
A | GLN47 |
A | PRO52 |
A | ALA55 |
A | HIS56 |
A | ALA59 |
A | PHE62 |
A | THR63 |
A | LEU67 |
A | VAL134 |
A | ARG136 |
A | TYR356 |
A | THR360 |
A | PRO364 |
A | ZWI504 |
A | HOH610 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue ZWI A 504 |
Chain | Residue |
A | TYR38 |
A | PHE62 |
A | F54503 |
site_id | AC5 |
Number of Residues | 25 |
Details | binding site for residue FMN B 501 |
Chain | Residue |
B | ALA95 |
B | ALA96 |
B | GLY97 |
B | LYS100 |
B | SER120 |
B | ASN145 |
B | ASN181 |
B | ASN212 |
B | LYS255 |
B | THR283 |
B | ASN284 |
B | THR285 |
B | SER305 |
B | GLY306 |
B | LEU309 |
B | VAL333 |
B | GLY334 |
B | GLY335 |
B | LEU355 |
B | TYR356 |
B | THR357 |
B | ORO502 |
B | HOH627 |
B | HOH628 |
B | HOH673 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue ORO B 502 |
Chain | Residue |
B | LYS100 |
B | ASN145 |
B | TYR147 |
B | GLY148 |
B | PHE149 |
B | ASN212 |
B | ASN284 |
B | THR285 |
B | FMN501 |
site_id | AC7 |
Number of Residues | 19 |
Details | binding site for residue F54 B 503 |
Chain | Residue |
B | LEU68 |
B | VAL134 |
B | ARG136 |
B | TYR356 |
B | THR360 |
B | PRO364 |
B | ZWI504 |
B | HOH620 |
B | HOH732 |
B | TYR38 |
B | MET43 |
B | LEU46 |
B | GLN47 |
B | PRO52 |
B | ALA55 |
B | HIS56 |
B | ALA59 |
B | PHE62 |
B | THR63 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue ZWI B 504 |
Chain | Residue |
B | PHE62 |
B | F54503 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZWI B 505 |
Chain | Residue |
B | LEU84 |
B | GLY85 |
B | ARG241 |
B | ARG249 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | SER215 | |
B | SER215 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 |
Chain | Residue | Details |
A | ALA96 | |
B | ALA96 | |
B | SER120 | |
B | ASN181 | |
B | ASN212 | |
B | LYS255 | |
B | THR283 | |
B | GLY306 | |
B | GLY335 | |
B | TYR356 | |
A | SER120 | |
A | ASN181 | |
A | ASN212 | |
A | LYS255 | |
A | THR283 | |
A | GLY306 | |
A | GLY335 | |
A | TYR356 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS100 | |
A | ASN145 | |
A | ASN284 | |
B | LYS100 | |
B | ASN145 | |
B | ASN284 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 109 |
Chain | Residue | Details |
A | ASN145 | electrostatic stabiliser |
A | PHE149 | activator, electrostatic stabiliser, enhance reactivity, polar/non-polar interaction |
A | SER215 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar/non-polar interaction, proton acceptor, proton donor, proton relay |
A | ASN217 | electrostatic stabiliser |
A | THR218 | activator, electrostatic stabiliser, enhance reactivity, hydrogen bond acceptor |
A | LYS255 | electrostatic stabiliser, hydrogen bond donor |
A | ASN284 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 109 |
Chain | Residue | Details |
B | ASN145 | electrostatic stabiliser |
B | PHE149 | activator, electrostatic stabiliser, enhance reactivity, polar/non-polar interaction |
B | SER215 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar/non-polar interaction, proton acceptor, proton donor, proton relay |
B | ASN217 | electrostatic stabiliser |
B | THR218 | activator, electrostatic stabiliser, enhance reactivity, hydrogen bond acceptor |
B | LYS255 | electrostatic stabiliser, hydrogen bond donor |
B | ASN284 | electrostatic stabiliser |