6CJG
Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 374 | 40752.4 | 1 | UniProt (Q02127) Pfam (PF01180) In PDB | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
2 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
3 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
4 | A | 2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid | non-polymer | 340.4 | 1 | Chemie (F51) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
7 | A | 3-[decyl(dimethyl)ammonio]propane-1-sulfonate | non-polymer | 307.5 | 1 | Chemie (ZWI) | |||
8 | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 33 - 396 (UniProt: Q02127)
PDB | External Database | Details |
---|---|---|
Leu 397 | - | expression tag |
Glu 398 | - | expression tag |
Ala 399 | - | expression tag |
Gly 400 | - | expression tag |
His 401 | - | expression tag |
His 402 | - | expression tag |
His 403 | - | expression tag |
His 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40752.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1448.5 | |
All* | Total formula weight | 42200.9 |