6CJG
Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 374 | 40752.4 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | B (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | C (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 4 | D (A) | 2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid | non-polymer | 340.4 | 1 | Chemie (F51) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | G (A) | 3-[decyl(dimethyl)ammonio]propane-1-sulfonate | non-polymer | 307.5 | 1 | Chemie (ZWI) | |||
| 8 | H (A) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 33 - 396 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| Leu 397 | - | expression tag |
| Glu 398 | - | expression tag |
| Ala 399 | - | expression tag |
| Gly 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40752.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1448.5 | |
| All* | Total formula weight | 42200.9 |
