6CFO

HUMAN PYRUVATE DEHYDROGENASE E1 COMPONENT COMPLEX WITH COVALENT TDP ADDUCT ACETYL PHOSPHINATE

Summary for 6CFO

Entry DOI	10.2210/pdb6cfo/pdb
Related	6CER
Descriptor	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-hydroxy-1-[(R)-hydroxy(oxo)-lambda~5~-phosphanyl]ethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ... (5 entities in total)
Functional Keywords	thiamin pyrophosphate, acetyl phosphinate, inhibitor, pyruvate dehydrogenase, oxidoreductase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	157237.95
Authors	ARJUNAN, P.,WHITLEY, M.J.,FUREY, W. (deposition date: 2018-02-15, release date: 2018-07-11, Last modification date: 2023-10-04)
Primary citation	Whitley, M.J.,Arjunan, P.,Nemeria, N.S.,Korotchkina, L.G.,Park, Y.H.,Patel, M.S.,Jordan, F.,Furey, W. Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alpha V138M variant of human pyruvate dehydrogenase. J. Biol. Chem., 293:13204-13213, 2018 Cited by PubMed: 29970614 DOI: 10.1074/jbc.RA118.003996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation