6CFD
ADEP4 bound to E. faecium ClpP
Summary for 6CFD
Entry DOI | 10.2210/pdb6cfd/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide, ... (4 entities in total) |
Functional Keywords | clpp, adep4, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Enterococcus faecium (Streptococcus faecium) |
Total number of polymer chains | 14 |
Total formula weight | 336298.86 |
Authors | Lee, R.E.,Griffith, E.C. (deposition date: 2018-02-14, release date: 2018-05-16, Last modification date: 2023-10-04) |
Primary citation | Brown Gandt, A.,Griffith, E.C.,Lister, I.M.,Billings, L.L.,Han, A.,Tangallapally, R.,Zhao, Y.,Singh, A.P.,Lee, R.E.,LaFleur, M.D. In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 29784838DOI: 10.1128/AAC.00424-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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