Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CFD

ADEP4 bound to E. faecium ClpP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005737	cellular_component	cytoplasm
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008236	molecular_function	serine-type peptidase activity
S	0009368	cellular_component	endopeptidase Clp complex
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008236	molecular_function	serine-type peptidase activity
T	0009368	cellular_component	endopeptidase Clp complex
T	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MPD A 401

Chain	Residue
A	SER98
A	MET99
A	SER101
A	ILE122
A	HIS123
A	PRO125
A	LEU150

site_id	AC2
Number of Residues	10
Details	binding site for residue EZA A 402

Chain	Residue
A	TYR63
A	GLN89
A	MET93
A	LEU115
A	MET190
B	LEU49
B	THR80
B	PHE83
A	ASP27
A	TYR61

site_id	AC3
Number of Residues	6
Details	binding site for residue MPD B 401

Chain	Residue
B	SER98
B	MET99
B	SER101
B	ILE122
B	HIS123
B	PRO125

site_id	AC4
Number of Residues	7
Details	binding site for residue MPD C 401

Chain	Residue
C	SER98
C	MET99
C	SER101
C	ILE122
C	HIS123
C	PRO125
C	LEU150

site_id	AC5
Number of Residues	8
Details	binding site for residue EZA C 402

Chain	Residue
C	ARG23
C	ASP27
C	TYR61
C	TYR63
C	GLN89
C	MET93
C	MET190
D	PHE83

site_id	AC6
Number of Residues	8
Details	binding site for residue MPD D 401

Chain	Residue
D	SER98
D	MET99
D	SER101
D	ILE122
D	HIS123
D	GLN124
D	PRO125
D	LEU150

site_id	AC7
Number of Residues	12
Details	binding site for residue EZA D 402

Chain	Residue
D	ARG23
D	ASP27
D	ILE29
D	TYR61
D	TYR63
D	GLN89
D	MET93
D	MET190
D	HOH501
E	PHE50
E	THR80
E	PHE83

site_id	AC8
Number of Residues	7
Details	binding site for residue MPD E 401

Chain	Residue
E	SER98
E	MET99
E	SER101
E	ILE122
E	HIS123
E	GLN124
E	PRO125

site_id	AC9
Number of Residues	11
Details	binding site for residue EZA E 402

Chain	Residue
E	ARG23
E	ASP27
E	ILE29
E	TYR61
E	TYR63
E	GLN89
E	MET93
E	LEU115
E	MET190
F	ALA53
F	PHE83

site_id	AD1
Number of Residues	8
Details	binding site for residue MPD F 401

Chain	Residue
F	SER98
F	MET99
F	SER101
F	ILE122
F	HIS123
F	GLN124
F	PRO125
F	LEU150

site_id	AD2
Number of Residues	11
Details	binding site for residue EZA F 402

Chain	Residue
F	ASP27
F	ILE29
F	TYR61
F	TYR63
F	GLN89
F	MET93
F	MET190
G	LEU49
G	PHE50
G	THR80
G	PHE83

site_id	AD3
Number of Residues	9
Details	binding site for residue MPD G 401

Chain	Residue
G	HIS123
G	GLN124
G	PRO125
G	LEU150
G	LEU154
G	SER98
G	MET99
G	SER101
G	ILE122

site_id	AD4
Number of Residues	7
Details	binding site for residue MPD I 401

Chain	Residue
I	SER98
I	MET99
I	SER101
I	ILE122
I	HIS123
I	PRO125
I	LEU150

site_id	AD5
Number of Residues	12
Details	binding site for residue EZA I 402

Chain	Residue
I	ASP27
I	ILE29
I	TYR61
I	TYR63
I	GLN89
I	MET93
I	PHE113
I	MET190
K	PHE50
K	ALA53
K	THR80
K	PHE83

site_id	AD6
Number of Residues	8
Details	binding site for residue MPD K 401

Chain	Residue
K	SER98
K	MET99
K	SER101
K	ILE122
K	HIS123
K	GLN124
K	PRO125
K	LEU150

site_id	AD7
Number of Residues	8
Details	binding site for residue MPD L 401

Chain	Residue
L	SER98
L	MET99
L	SER101
L	ILE122
L	HIS123
L	GLN124
L	PRO125
L	LEU150

site_id	AD8
Number of Residues	12
Details	binding site for residue EZA L 402

Chain	Residue
L	ASP27
L	ILE29
L	TYR61
L	TYR63
L	GLN89
L	MET93
L	MET190
M	LEU49
M	PHE50
M	ALA53
M	THR80
M	PHE83

site_id	AD9
Number of Residues	9
Details	binding site for residue MPD M 401

Chain	Residue
M	SER98
M	MET99
M	SER101
M	ILE122
M	HIS123
M	GLN124
M	PRO125
M	LEU150
M	LEU154

site_id	AE1
Number of Residues	12
Details	binding site for residue EZA M 402

Chain	Residue
M	ARG23
M	ASP27
M	ILE29
M	TYR61
M	TYR63
M	GLN89
M	MET93
M	MET190
N	PHE50
N	ALA53
N	THR80
N	PHE83

site_id	AE2
Number of Residues	7
Details	binding site for residue MPD N 401

Chain	Residue
N	SER98
N	MET99
N	SER101
N	ILE122
N	HIS123
N	PRO125
N	LEU150

site_id	AE3
Number of Residues	14
Details	binding site for residue EZA N 402

Chain	Residue
N	ARG23
N	ASP27
N	ILE29
N	TYR61
N	TYR63
N	GLN89
N	MET93
N	LEU115
N	MET190
N	HOH501
S	PHE50
S	ALA53
S	THR80
S	PHE83

site_id	AE4
Number of Residues	8
Details	binding site for residue MPD S 401

Chain	Residue
S	SER98
S	MET99
S	SER101
S	ILE122
S	HIS123
S	GLN124
S	PRO125
S	LEU150

site_id	AE5
Number of Residues	13
Details	binding site for residue EZA S 402

Chain	Residue
S	ARG23
S	ASP27
S	ILE29
S	TYR61
S	TYR63
S	GLN89
S	MET93
S	LEU115
S	MET190
T	LEU49
T	ALA53
T	THR80
T	PHE83

site_id	AE6
Number of Residues	7
Details	binding site for residue MPD T 401

Chain	Residue
T	SER98
T	MET99
T	SER101
T	ILE122
T	HIS123
T	PRO125
T	LEU150

site_id	AE7
Number of Residues	12
Details	binding site for residue EZA T 402

Chain	Residue
I	ALA53
I	THR80
I	PHE83
T	ARG23
T	ASP27
T	ILE29
T	TYR61
T	TYR63
T	GLN89
T	MET93
T	LEU115
T	MET190

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TivMGmAASMGS

Chain	Residue	Details
A	THR90-SER101

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnaeIMIHQP

Chain	Residue	Details
A	ARG112-PRO125

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)