6CBM

x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external aldimine) at pH 9

Summary for 6CBM

Entry DOI	10.2210/pdb6cbm/pdb
Descriptor	Neamine transaminase NeoN, (1R,2R,3S,4R,6S)-4,6-diamino-2-[(3-O-{2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranosyl}-beta-D-ribofuranosyl)oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	neomycin, aminotransferase, transferase
Biological source	Streptomyces fradiae
Total number of polymer chains	2
Total formula weight	96216.54
Authors	Thoden, J.B.,Dow, G.T.,Holden, H.M. (deposition date: 2018-02-03, release date: 2018-02-21, Last modification date: 2023-10-04)
Primary citation	Dow, G.T.,Thoden, J.B.,Holden, H.M. The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin. Protein Sci., 27:945-956, 2018 Cited by PubMed: 29516565 DOI: 10.1002/pro.3400 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation