6B6G
Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction
Summary for 6B6G
Entry DOI | 10.2210/pdb6b6g/pdb |
Descriptor | 4-aminobutyrate aminotransferase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, (3R,4E)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]cyclopent-1-ene-1,3-dicarboxylic acid, ... (6 entities in total) |
Functional Keywords | inactivator, gaba aminotransferase, plp, transferase |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 4 |
Total formula weight | 211620.30 |
Authors | Mascarenhas, R.,Juncosa, J.I.,Takaya, K.,Le, L.V.,Moschitto, M.J.,Silverman, R.B.,Liu, D. (deposition date: 2017-10-02, release date: 2018-02-14, Last modification date: 2024-03-13) |
Primary citation | Juncosa, J.I.,Takaya, K.,Le, H.V.,Moschitto, M.J.,Weerawarna, P.M.,Mascarenhas, R.,Liu, D.,Dewey, S.L.,Silverman, R.B. Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. J. Am. Chem. Soc., 140:2151-2164, 2018 Cited by PubMed: 29381352DOI: 10.1021/jacs.7b10965 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report