6B3S
Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R)
Summary for 6B3S
Entry DOI | 10.2210/pdb6b3s/pdb |
Descriptor | Epidermal growth factor receptor, Necitumumab Fab Heavy chain, Necitumumab Fab Light chain, ... (8 entities in total) |
Functional Keywords | therapeutic antibody, cetuximab resistance, somatic mutation, colorectal cancer, transferase, transferase-immune system complex, transferase/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 287582.73 |
Authors | Ferguson, K.M.,Bagchi, A. (deposition date: 2017-09-23, release date: 2017-12-06, Last modification date: 2023-10-04) |
Primary citation | Bagchi, A.,Haidar, J.N.,Eastman, S.W.,Vieth, M.,Topper, M.,Iacolina, M.D.,Walker, J.M.,Forest, A.,Shen, Y.,Novosiadly, R.D.,Ferguson, K.M. Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Mol. Cancer Ther., 17:521-531, 2018 Cited by PubMed: 29158469DOI: 10.1158/1535-7163.MCT-17-0575 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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