6B11

TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)

Summary for 6B11

• Entry DOI: 10.2210/pdb6b11/pdb
• Descriptor: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl 3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranoside, ... (5 entities in total)
• Functional Keywords: p450, tylosin biosynthesis, oxidoreductase
• Biological source: Streptomyces fradiae (Streptomyces roseoflavus)
• Total number of polymer chains: 2
• Total formula weight: 99115.46

Authors

DeMars, M.D.,Sherman, D.H.,Podust, L.M. (deposition date: 2017-09-15, release date: 2018-12-19, Last modification date: 2023-11-15)

• Primary citation: DeMars, M.D.,Sherman, D.H.,Podust, L.M.; TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.99 Å)