6B11

TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	20-oxo-5-O-mycaminosyltylactone 23-monooxygenase	polymer	440	47800.9	2	UniProt (Q9ZHQ1) Pfam (PF00067)	Streptomyces fradiae (Streptomyces roseoflavus)	Cytochrome P-450 monooxygenase TylH1
2	C, S (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	D, T (A, B)	(4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl 3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranoside	non-polymer		581.7	2	Chemie (CGM)
4	E, F, G, H, I... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	18	Chemie (EDO)
5	Y, Z (A, B)	water	water		18.0	234	Chemie (HOH)

Sequence modifications

A, B: 1 - 420 (UniProt: Q9ZHQ1)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95601.8
Non-Polymers*	Number of molecules	22
	Total formula weight	3513.7
All*	Total formula weight	99115.5

*Water molecules are not included.