6AWQ
Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site
Summary for 6AWQ
Entry DOI | 10.2210/pdb6awq/pdb |
Descriptor | Sodium-dependent serotonin transporter, 8B6 antibody FAB heavy chain, 8B6 antibody FAB light chain, ... (8 entities in total) |
Functional Keywords | neurotransmitter transporter, antidepressant, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 111478.33 |
Authors | Coleman, J.A.,Gouaux, E. (deposition date: 2017-09-06, release date: 2017-10-25, Last modification date: 2023-10-04) |
Primary citation | Coleman, J.A.,Gouaux, E. Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25:170-175, 2018 Cited by PubMed: 29379174DOI: 10.1038/s41594-018-0026-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.046 Å) |
Structure validation
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