6AFK

Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor

Summary for 6AFK

• Entry DOI: 10.2210/pdb6afk/pdb
• Descriptor: tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE, N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide, ... (4 entities in total)
• Functional Keywords: trna methyltransferase, transferase
• Biological source: Pseudomonas aeruginosa UCBPP-PA14
• Total number of polymer chains: 2
• Total formula weight: 61457.21

Authors

Zhong, W.,Koay, A.,Wong, Y.W.,Sahili, A.E.,Nah, Q.,Kang, C.,Poulsen, A.,Chionh, Y.K.,McBee, M.,Matter, A.,Hill, J.,Lescar, J.,Dedon, P.C. (deposition date: 2018-08-08, release date: 2019-08-14, Last modification date: 2023-11-22)

• Primary citation: Zhong, W.,Koay, A.,Ngo, A.,Li, Y.,Nah, Q.,Wong, Y.H.,Chionh, Y.H.,Ng, H.Q.,Koh-Stenta, X.,Poulsen, A.,Foo, K.,McBee, M.,Choong, M.L.,El Sahili, A.,Kang, C.,Matter, A.,Lescar, J.,Hill, J.,Dedon, P.; Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.; Acs Infect Dis., 5:326-335, 2019; PubMed: 30682246; DOI: 10.1021/acsinfecdis.8b00275

Experimental method

X-RAY DIFFRACTION (2.75 Å)