6AFK

Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	tRNA (guanine-N(1)-)-methyltransferase	polymer	269	30336.2	2	UniProt (Q02RL6) Pfam (PF01746) In PDB	Pseudomonas aeruginosa UCBPP-PA14	M1G-methyltransferase,tRNA [GM37] methyltransferase
2	A	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)
3	B	N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide	non-polymer		386.4	1	Chemie (9WO)
4		water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B: 5 - 250 (UniProt: Q02RL6)

PDB	External Database	Details
Met -18	-	initiating methionine
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Val -8	-	expression tag
Asp -7	-	expression tag
Leu -6	-	expression tag
Gly -5	-	expression tag
Thr -4	-	expression tag
Glu -3	-	expression tag
Asn -2	-	expression tag
Leu -1	-	expression tag
Tyr 0	-	expression tag
Phe 1	-	expression tag
Gln 2	-	expression tag
Ser 3	-	expression tag
Met 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60672.3
Non-Polymers*	Number of molecules	2
	Total formula weight	784.9
All*	Total formula weight	61457.2

*Water molecules are not included.