6A5W
FXR-LBD with HNC143 and SRC1
Summary for 6A5W
Entry DOI | 10.2210/pdb6a5w/pdb |
Descriptor | Bile acid receptor, Nuclear receptor coactivator 1, 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, coactivator, agonist, complex, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 57657.64 |
Authors | |
Primary citation | Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J. Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293:18180-18191, 2018 Cited by PubMed: 30275017DOI: 10.1074/jbc.RA118.004652 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
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