6A5W

FXR-LBD with HNC143 and SRC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0032052	molecular_function	bile acid binding
C	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 9R0 A 501

Chain	Residue
A	THR270
A	ILE335
A	HIS344
A	HIS447
A	TRP454
A	PHE461
A	TRP469
A	ILE273
A	LEU287
A	THR288
A	MET290
A	ALA291
A	MET328
A	PHE329
A	SER332

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site_id	AC2
Number of Residues	16
Details	binding site for residue 9R0 C 501

Chain	Residue
C	THR270
C	LEU287
C	THR288
C	MET290
C	ALA291
C	MET328
C	PHE329
C	SER332
C	ILE335
C	HIS344
C	LEU348
C	TYR369
C	HIS447
C	TRP454
C	PHE461
C	TRP469

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG331
A	TYR361
A	TYR369
A	HIS447
C	ARG331
C	TYR361
C	TYR369
C	HIS447

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR442
C	THR442

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LYS275
C	LYS275

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