6A5W
FXR-LBD with HNC143 and SRC1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Bile acid receptor | polymer | 228 | 26726.6 | 2 | UniProt (Q96RI1) Pfam (PF00104) | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
| 2 | B, D (B, D) | Nuclear receptor coactivator 1 | polymer | 12 | 1531.7 | 2 | UniProt (B5MCN7) UniProt (by SIFTS) (Q15788) | Homo sapiens | |
| 3 | E, F (A, C) | 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid | non-polymer | 570.5 | 2 | Chemie (9R0) | |||
| 4 | G, H, I (A, B, C) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, C: 244 - 471 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Glu 432 | Cys 446 | engineered mutation |
| Glu 466 | Cys 480 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 56516.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 57657.6 |
