6A1F
Crystal structure of human DYRK1A in complex with compound 14
Summary for 6A1F
Entry DOI | 10.2210/pdb6a1f/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, 8-methoxy-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine, ... (5 entities in total) |
Functional Keywords | dyrk1a, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42886.29 |
Authors | Baba, D.,Hanzawa, H. (deposition date: 2018-06-07, release date: 2018-10-03, Last modification date: 2024-10-16) |
Primary citation | Fukuda, T.,Ishiyama, T.,Katagiri, T.,Ueda, K.,Muramatsu, S.,Hashimoto, M.,Aki, A.,Baba, D.,Watanabe, K.,Tanaka, N. Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives. Bioorg. Med. Chem. Lett., 28:3333-3337, 2018 Cited by PubMed: 30217414DOI: 10.1016/j.bmcl.2018.09.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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