6A1F
Crystal structure of human DYRK1A in complex with compound 14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 360 | 41904.4 | 1 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
| 2 | B, C, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | H (A) | 8-methoxy-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine | non-polymer | 255.3 | 1 | Chemie (9OF) | |||
| 4 | I (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 5 | J (A) | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A: 127 - 483 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | expression tag |
| Pro 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41904.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 981.9 | |
| All* | Total formula weight | 42886.3 |
