5ZXI

Co-crystal structure of an Inhibitor in complex with human PPARdelta LBD

Summary for 5ZXI

• Entry DOI: 10.2210/pdb5zxi/pdb
• Related: 5XMX
• Descriptor: Peroxisome proliferator-activated receptor delta, 6-[2-({2-[4-(furan-2-yl)phenyl]-5-methyl-1H-imidazol-1-yl}methyl)phenoxy]hexanoic acid (3 entities in total)
• Functional Keywords: ppardelta, inhibitor compound co-crystal structure, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 63750.11

Authors

Rani, S.T.,Laxminarasimhan, A.,Senaiar, R.S.,Krishnamurthy, N. (deposition date: 2018-05-21, release date: 2019-04-03, Last modification date: 2024-03-27)

• Primary citation: Lagu, B.,Kluge, A.F.,Tozzo, E.,Fredenburg, R.,Bell, E.L.,Goddeeris, M.M.,Dwyer, P.,Basinski, A.,Senaiar, R.S.,Jaleel, M.,Tiwari, N.K.,Panigrahi, S.K.,Krishnamurthy, N.R.,Takahashi, T.,Patane, M.A.; Selective PPAR delta Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).; ACS Med Chem Lett, 9:935-940, 2018; PubMed: 30258544; DOI: 10.1021/acsmedchemlett.8b00287

Experimental method

X-RAY DIFFRACTION (2.1 Å)