5XMX

Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD

Summary for 5XMX

Entry DOI	10.2210/pdb5xmx/pdb
Descriptor	Peroxisome proliferator-activated receptor delta, (E)-6-[2-[[[4-(furan-2-yl)phenyl]carbonyl-methyl-amino]methyl]phenoxy]-4-methyl-hex-4-enoic acid (3 entities in total)
Functional Keywords	ppardelta, inhibitor compound, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q03181
Total number of polymer chains	2
Total formula weight	63728.06
Authors	Lakshminarasimhan, A.,Rani, S.T.,Senaiar, R.S.,Krishnamurthy, N. (deposition date: 2017-05-16, release date: 2018-05-23, Last modification date: 2023-11-22)
Primary citation	Lagu, B.,Kluge, A.F.,Fredenburg, R.A.,Tozzo, E.,Senaiar, R.S.,Jaleel, M.,Panigrahi, S.K.,Tiwari, N.K.,Krishnamurthy, N.R.,Takahashi, T.,Patane, M.A. Novel highly selective peroxisome proliferator-activated receptor delta (PPAR delta) modulators with pharmacokinetic properties suitable for once-daily oral dosing. Bioorg. Med. Chem. Lett., 27:5230-5234, 2017 Cited by PubMed: 29103972 DOI: 10.1016/j.bmcl.2017.10.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation