5ZWJ
Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045
Summary for 5ZWJ
Entry DOI | 10.2210/pdb5zwj/pdb |
Descriptor | Epidermal growth factor receptor, (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide (3 entities in total) |
Functional Keywords | egfr t790m, c797s, eai045, signaling protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41224.58 |
Authors | |
Primary citation | Zhao, P.,Yao, M.Y.,Zhu, S.J.,Chen, J.Y.,Yun, C.H. Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem. Biophys. Res. Commun., 502:332-337, 2018 Cited by PubMed: 29802850DOI: 10.1016/j.bbrc.2018.05.154 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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