5ZWJ
Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 355 | 40841.2 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide | non-polymer | 383.4 | 1 | Chemie (9LL) | |||
| 3 | C (A) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 675 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 674 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Ser 797 | Cys 797 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
| His 1023 | - | expression tag |
| His 1024 | - | expression tag |
| His 1025 | - | expression tag |
| His 1026 | - | expression tag |
| His 1027 | - | expression tag |
| His 1028 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40841.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 383.4 | |
| All* | Total formula weight | 41224.6 |
