5ZWJ

Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epidermal growth factor receptor	polymer	355	40841.2	1	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (Human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2	A	(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide	non-polymer		383.4	1	Chemie (9LL)
3		water	water		18.0	24	Chemie (HOH)

Sequence modifications

A: 675 - 1022 (UniProt: P00533)

PDB	External Database	Details
Gly 674	-	expression tag
Met 790	Thr 790	engineered mutation
Ser 797	Cys 797	engineered mutation
Arg 948	Val 948	engineered mutation
His 1023	-	expression tag
His 1024	-	expression tag
His 1025	-	expression tag
His 1026	-	expression tag
His 1027	-	expression tag
His 1028	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40841.2
Non-Polymers*	Number of molecules	1
	Total formula weight	383.4
All*	Total formula weight	41224.6

*Water molecules are not included.