5ZV2

FGFR-1 in complex with ligand lenvatinib

5ZV2 の概要

• エントリーDOI: 10.2210/pdb5zv2/pdb
• 分子名称: Fibroblast growth factor receptor 1, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide (3 entities in total)
• 機能のキーワード: fgf receptor kinase, transferase-transferase inhibitor complex, biosynthetic protein, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70503.82

構造登録者

Matsuki, M.,Hoshi, T.,Yamamoto, Y.,Ikemori-Kawada, M.,Minoshima, Y.,Funahashi, Y.,Matsui, J. (登録日: 2018-05-09, 公開日: 2018-07-11, 最終更新日: 2023-11-22)

• 主引用文献: Matsuki, M.,Hoshi, T.,Yamamoto, Y.,Ikemori-Kawada, M.,Minoshima, Y.,Funahashi, Y.,Matsui, J.; Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.; Cancer Med, 7:2641-2653, 2018; PubMed: 29733511; DOI: 10.1002/cam4.1517

実験手法

X-RAY DIFFRACTION (2.86 Å)