Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21

Summary for 5ZRF

DescriptorDNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... (6 entities in total)
Functional Keywordstype ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight198128.89
Chen, S.F.,Wang, Y.R.,Wu, C.C.,Chan, N.L. (deposition date: 2018-04-24, release date: 2018-08-08, Last modification date: 2019-02-20)
Primary citation
Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L.
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9:3085-3085, 2018
PubMed: 30082834 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-05406-y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22640 0.3% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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