5ZM6
Crystal structure of ORP1-ORD in complex with PI(4,5)P2
Summary for 5ZM6
Entry DOI | 10.2210/pdb5zm6/pdb |
Descriptor | Oxysterol-binding protein-related protein 1, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate, ACETATE ION, ... (4 entities in total) |
Functional Keywords | transporter, complex, phospholipid, lipid transport |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 103268.90 |
Authors | |
Primary citation | Dong, J.,Du, X.,Wang, H.,Wang, J.,Lu, C.,Chen, X.,Zhu, Z.,Luo, Z.,Yu, L.,Brown, A.J.,Yang, H.,Wu, J.W. Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun, 10:829-829, 2019 Cited by PubMed: 30783101DOI: 10.1038/s41467-019-08791-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report