5ZJF

LDHA-MA

Summary for 5ZJF

• Entry DOI: 10.2210/pdb5zjf/pdb
• Descriptor: L-lactate dehydrogenase A chain, 5,5'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]bis(2H-1,3-benzodioxole) (3 entities in total)
• Functional Keywords: ldha, inhibitor, machilin a, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 12
• Total formula weight: 449514.65

Authors

Han, C.W.,Jang, S.B. (deposition date: 2018-03-20, release date: 2019-07-24, Last modification date: 2023-11-22)

• Primary citation: Chung, T.-W.,Kim, E.-Y.,Han, C.W.,Park, S.Y.,Jeong, M.S.,Yoon, D.,Choi, H.-J.,Jin, L.,Park, M.-J.,Kwon, Y.J.,Lee, H.,Kim, K.-J.,Park, K.H.,Kim, S.,Jang, S.B.,Ha, K.-T.; Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid.; Cancers (Basel), 11:-, 2019; PubMed: 31324019; DOI: 10.3390/cancers11070963

Experimental method

X-RAY DIFFRACTION (2.602 Å)