5ZJ6
Crystal structure of HCK kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Summary for 5ZJ6
Entry DOI | 10.2210/pdb5zj6/pdb |
Descriptor | Tyrosine-protein kinase HCK, 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | kinase/kinase inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 66170.29 |
Authors | Tomabechi, Y.,Kukimoto-Niino, M.,Shirouzu, M. (deposition date: 2018-03-19, release date: 2018-06-06, Last modification date: 2023-11-22) |
Primary citation | Katsura, K.,Tomabechi, Y.,Matsuda, T.,Yonemochi, M.,Mikuni, J.,Ohsawa, N.,Terada, T.,Yokoyama, S.,Kukimoto-Niino, M.,Takemoto, C.,Shirouzu, M. Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression. Protein Expr. Purif., 150:92-99, 2018 Cited by PubMed: 29793032DOI: 10.1016/j.pep.2018.05.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.696 Å) |
Structure validation
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