5ZG2
Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2
Summary for 5ZG2
Entry DOI | 10.2210/pdb5zg2/pdb |
Descriptor | Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ... (7 entities in total) |
Functional Keywords | ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 60498.95 |
Authors | Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2018-03-07, release date: 2019-01-16, Last modification date: 2023-11-22) |
Primary citation | Kunugi, A.,Tanaka, M.,Suzuki, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Nakamura, S.,Kuno, H.,Yokota, A.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H. TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44:961-970, 2019 Cited by PubMed: 30209408DOI: 10.1038/s41386-018-0213-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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