5ZG2

Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2

5ZG2 の概要

• エントリーDOI: 10.2210/pdb5zg2/pdb
• 分子名称: Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ... (7 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60498.95

構造登録者

Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (登録日: 2018-03-07, 公開日: 2019-01-16, 最終更新日: 2023-11-22)

• 主引用文献: Kunugi, A.,Tanaka, M.,Suzuki, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Nakamura, S.,Kuno, H.,Yokota, A.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H.; TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.; Neuropsychopharmacology, 44:961-970, 2019; PubMed: 30209408; DOI: 10.1038/s41386-018-0213-7

実験手法

X-RAY DIFFRACTION (1.25 Å)