5ZE6

CRYSTAL STRUCTURE OF OCTAPRENYL PYROPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI WITH BPH-981

Summary for 5ZE6

Entry DOI	10.2210/pdb5ze6/pdb
Descriptor	Octaprenyl diphosphate synthase, 2-hydroxy-6-(tetradecyloxy)benzoic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	prenyltransferase, site-directed mutagenesis, product chain length, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli K-12
Total number of polymer chains	4
Total formula weight	141749.11
Authors	Han, X.,Liu, W.D.,Zheng, Y.Y.,Ko, T.P.,Chen, C.C.,Guo, R.T. (deposition date: 2018-02-26, release date: 2019-02-27, Last modification date: 2023-11-22)
Primary citation	Malwal, S.R.,Chen, L.,Hicks, H.,Qu, F.,Liu, W.,Shillo, A.,Law, W.X.,Zhang, J.,Chandnani, N.,Han, X.,Zheng, Y.,Chen, C.C.,Guo, R.T.,AbdelKhalek, A.,Seleem, M.N.,Oldfield, E. Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. J.Med.Chem., 62:2564-2581, 2019 Cited by PubMed: 30730737 DOI: 10.1021/acs.jmedchem.8b01878 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation