5ZBQ

The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299

Summary for 5ZBQ

• Entry DOI: 10.2210/pdb5zbq/pdb
• Related: 5ZBH
• Descriptor: Neuropeptide Y receptor type 1,T4 Lysozyme, N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino)ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide (2 entities in total)
• Functional Keywords: g protein-coupled receptor, receptor inhibitor, complex structure, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Host cytoplasm : A0A097J792
• Total number of polymer chains: 1
• Total formula weight: 61210.95

Authors

Yang, Z.,Han, S.,Zhao, Q.,Wu, B. (deposition date: 2018-02-12, release date: 2018-04-25, Last modification date: 2023-11-22)

• Primary citation: Yang, Z.,Han, S.,Keller, M.,Kaiser, A.,Bender, B.J.,Bosse, M.,Burkert, K.,Kogler, L.M.,Wifling, D.,Bernhardt, G.,Plank, N.,Littmann, T.,Schmidt, P.,Yi, C.,Li, B.,Ye, S.,Zhang, R.,Xu, B.,Larhammar, D.,Stevens, R.C.,Huster, D.,Meiler, J.,Zhao, Q.,Beck-Sickinger, A.G.,Buschauer, A.,Wu, B.; Structural basis of ligand binding modes at the neuropeptide Y Y1receptor; Nature, 556:520-524, 2018; PubMed: 29670288; DOI: 10.1038/s41586-018-0046-x

Experimental method

X-RAY DIFFRACTION (2.7 Å)