5Z79
Crystal Structure Analysis of the HPPK-DHPS in complex with substrates
Summary for 5Z79
Entry DOI | 10.2210/pdb5z79/pdb |
Descriptor | Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (8 entities in total) |
Functional Keywords | trasnferase, bifunctional, malaria pterin, substrates, transferase |
Biological source | Plasmodium vivax (malaria parasite P. vivax) |
Total number of polymer chains | 6 |
Total formula weight | 500109.67 |
Authors | Manickam, Y.,Karl, H.,Sharma, A. (deposition date: 2018-01-27, release date: 2018-08-29, Last modification date: 2023-11-22) |
Primary citation | Yogavel, M.,Nettleship, J.E.,Sharma, A.,Harlos, K.,Jamwal, A.,Chaturvedi, R.,Sharma, M.,Jain, V.,Chhibber-Goel, J.,Sharma, A. Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance J. Biol. Chem., 293:14962-14972, 2018 Cited by PubMed: 30104413DOI: 10.1074/jbc.RA118.004558 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report