Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5Z79

Crystal Structure Analysis of the HPPK-DHPS in complex with substrates

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A	0004156	molecular_function	dihydropteroate synthase activity
A	0005524	molecular_function	ATP binding
A	0005740	cellular_component	mitochondrial envelope
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
B	0004156	molecular_function	dihydropteroate synthase activity
B	0005524	molecular_function	ATP binding
B	0005740	cellular_component	mitochondrial envelope
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
C	0004156	molecular_function	dihydropteroate synthase activity
C	0005524	molecular_function	ATP binding
C	0005740	cellular_component	mitochondrial envelope
C	0009396	biological_process	folic acid-containing compound biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0042558	biological_process	pteridine-containing compound metabolic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046656	biological_process	folic acid biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
D	0004156	molecular_function	dihydropteroate synthase activity
D	0005524	molecular_function	ATP binding
D	0005740	cellular_component	mitochondrial envelope
D	0009396	biological_process	folic acid-containing compound biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0042558	biological_process	pteridine-containing compound metabolic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046656	biological_process	folic acid biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
E	0004156	molecular_function	dihydropteroate synthase activity
E	0005524	molecular_function	ATP binding
E	0005740	cellular_component	mitochondrial envelope
E	0009396	biological_process	folic acid-containing compound biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0042558	biological_process	pteridine-containing compound metabolic process
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046656	biological_process	folic acid biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
F	0004156	molecular_function	dihydropteroate synthase activity
F	0005524	molecular_function	ATP binding
F	0005740	cellular_component	mitochondrial envelope
F	0009396	biological_process	folic acid-containing compound biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0042558	biological_process	pteridine-containing compound metabolic process
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046656	biological_process	folic acid biosynthetic process
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue HH2 A 1101

Chain	Residue
A	ASN342
A	ASP547
A	PHE552
A	PHE575
A	GLY577
A	LYS581
A	ARG697
A	HIS699
A	PAB1103
A	MG1104
A	SER347
A	PHE348
A	SER381
A	SER382
A	ALA383
A	ASP454
A	ASN474
A	MET501

site_id	AC2
Number of Residues	11
Details	binding site for residue APC A 1102

Chain	Residue
A	ARG204
A	ASP207
A	ASP209
A	ILE210
A	ILE259
A	GLU260
A	PHE261
A	CYS263
A	HIS266
A	ARG272
A	PE01105

site_id	AC3
Number of Residues	9
Details	binding site for residue PAB A 1103

Chain	Residue
A	PHE348
A	SER382
A	ALA383
A	GLY551
A	PHE552
A	LYS581
A	ARG582
A	HH21101
A	HOH1226

site_id	AC4
Number of Residues	3
Details	binding site for residue MG A 1104

Chain	Residue
A	ASN342
A	ARG697
A	HH21101

site_id	AC5
Number of Residues	7
Details	binding site for residue PE0 A 1105

Chain	Residue
A	THR54
A	GLU57
A	PHE160
A	ASN162
A	ARG272
A	SER274
A	APC1102

site_id	AC6
Number of Residues	18
Details	binding site for residue HH2 B 1101

Chain	Residue
B	ASN342
B	SER347
B	PHE348
B	SER381
B	SER382
B	ALA383
B	ASP454
B	ASN474
B	MET501
B	ASP547
B	PHE552
B	PHE575
B	GLY577
B	LYS581
B	ARG697
B	HIS699
B	PAB1103
B	HOH1202

site_id	AC7
Number of Residues	8
Details	binding site for residue 5AD B 1102

Chain	Residue
B	LEU178
B	ASP209
B	ILE210
B	LYS258
B	GLU260
B	PHE261
B	CYS263
B	HIS266

site_id	AC8
Number of Residues	10
Details	binding site for residue PAB B 1103

Chain	Residue
B	PHE348
B	SER382
B	ALA383
B	PRO384
B	GLY551
B	PHE552
B	LYS581
B	ARG582
B	HH21101
B	HOH1204

site_id	AC9
Number of Residues	17
Details	binding site for residue HH2 C 1101

Chain	Residue
C	PAB1103
C	MG1104
C	ASN342
C	SER347
C	PHE348
C	SER381
C	SER382
C	ALA383
C	ASP454
C	ASN474
C	ILE476
C	MET501
C	ASP547
C	GLY577
C	LYS581
C	ARG697
C	HIS699

site_id	AD1
Number of Residues	12
Details	binding site for residue APC C 1102

Chain	Residue
C	LEU178
C	LYS182
C	ARG204
C	ASP207
C	ASP209
C	ILE210
C	ILE259
C	GLU260
C	PHE261
C	CYS263
C	HIS266
C	ARG272

site_id	AD2
Number of Residues	7
Details	binding site for residue PAB C 1103

Chain	Residue
C	SER382
C	ALA383
C	GLY551
C	PHE552
C	LYS581
C	ARG582
C	HH21101

site_id	AD3
Number of Residues	2
Details	binding site for residue MG C 1104

Chain	Residue
C	ASN342
C	HH21101

site_id	AD4
Number of Residues	8
Details	binding site for residue PE0 C 1105

Chain	Residue
C	THR54
C	VAL55
C	PRO56
C	GLU57
C	PHE160
C	ASN162
C	ARG272
C	SER274

site_id	AD5
Number of Residues	20
Details	binding site for residue HH2 D 1101

Chain	Residue
D	ILE340
D	ASN342
D	SER347
D	PHE348
D	SER381
D	SER382
D	ALA383
D	ASP454
D	ASN474
D	ILE476
D	MET501
D	ASP547
D	GLY577
D	LYS581
D	ARG697
D	HIS699
D	PAB1103
D	MG1104
D	HOH1214
D	HOH1224

site_id	AD6
Number of Residues	8
Details	binding site for residue 5AD D 1102

Chain	Residue
D	ASP209
D	ILE210
D	LYS258
D	ILE259
D	GLU260
D	PHE261
D	LEU262
D	CYS263

site_id	AD7
Number of Residues	9
Details	binding site for residue PAB D 1103

Chain	Residue
D	PHE348
D	SER382
D	ALA383
D	GLY551
D	PHE552
D	LYS581
D	ARG582
D	HH21101
D	HOH1227

site_id	AD8
Number of Residues	3
Details	binding site for residue MG D 1104

Chain	Residue
D	ASN342
D	HH21101
D	HOH1239

site_id	AD9
Number of Residues	6
Details	binding site for residue PE0 D 1105

Chain	Residue
D	VAL55
D	GLU57
D	PHE160
D	ASN162
D	ARG272
D	SER274

site_id	AE1
Number of Residues	17
Details	binding site for residue HH2 E 1101

Chain	Residue
E	ILE340
E	ASN342
E	SER347
E	PHE348
E	SER381
E	SER382
E	ASP454
E	ASN474
E	ILE476
E	MET501
E	ASP547
E	GLY577
E	LYS581
E	ARG697
E	HIS699
E	PAB1102
E	MG1103

site_id	AE2
Number of Residues	8
Details	binding site for residue PAB E 1102

Chain	Residue
E	SER382
E	ALA383
E	GLY551
E	PHE552
E	LYS581
E	ARG582
E	HH21101
E	HOH1206

site_id	AE3
Number of Residues	4
Details	binding site for residue MG E 1103

Chain	Residue
E	ASN342
E	GLU380
E	ASP454
E	HH21101

site_id	AE4
Number of Residues	7
Details	binding site for residue PE0 E 1104

Chain	Residue
E	THR54
E	GLU57
E	PHE160
E	ASN162
E	ARG272
E	SER274
E	HOH1208

site_id	AE5
Number of Residues	18
Details	binding site for residue HH2 F 1101

Chain	Residue
F	ILE340
F	ASN342
F	SER347
F	PHE348
F	SER381
F	SER382
F	ALA383
F	ASP454
F	ASN474
F	ILE476
F	MET501
F	ASP547
F	PHE575
F	GLY577
F	LYS581
F	ARG697
F	HIS699
F	PAB1102

site_id	AE6
Number of Residues	6
Details	binding site for residue PAB F 1102

Chain	Residue
F	SER382
F	ALA383
F	PHE552
F	LYS581
F	ARG582
F	HH21101

Functional Information from PROSITE/UniProt

site_id	PS00793
Number of Residues	14
Details	DHPS_2 Dihydropteroate synthase signature 2. GAsVIDIGGesSaP

Chain	Residue	Details
A	GLY371-PRO384

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)