5Z2U
ThDP-Mn2+ complex of R395A variant of EcMenD soaked with 2-ketoglutarate for 5 min
Summary for 5Z2U
Entry DOI | 10.2210/pdb5z2u/pdb |
Descriptor | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, MAGNESIUM ION, ... (8 entities in total) |
Functional Keywords | complex, transferase |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 8 |
Total formula weight | 496075.67 |
Authors | |
Primary citation | Qin, M.M.,Song, H.G.,Dai, X.,Chen, Y.Z.,Guo, Z.H. Two active site arginines are critical determinants of substrate binding and catalysis in MenD: a thiamine-dependent enzyme in menaquinone biosynthesis. Biochem. J., 475:3651-3667, 2018 Cited by PubMed: 30341164DOI: 10.1042/BCJ20180548 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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